4-Quinolone N-Oxides as Bacterial Weapons

D. Szamosvári; T. Böttcher

doi:10.1055/s-0036-1591913

Synlett, Table of Contents

Synlett 2018; 29(05): 542-547
DOI: 10.1055/s-0036-1591913

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4-Quinolone N-Oxides as Bacterial Weapons

D. Szamosvári

Dept. Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany Email: Thomas.Boettcher@uni-konstanz.de

,

T. Böttcher *

Dept. Chemistry, Konstanz Research School Chemical Biology, Zukunftskolleg, University of Konstanz, 78457 Konstanz, Germany Email: Thomas.Boettcher@uni-konstanz.de

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Abstract

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Abstract

Various bacterial species are known to produce metabolites of the 4-quinolone N-oxide class. These compounds have antibiotic activities, and are believed to target the respiration of competing microbes by interfering with menaquinone-binding sites in enzymes of the electron-transport chain. Interestingly, even minor structural changes in related N-oxides produced by the same organism can produce a dramatic difference in antibiotic activity, suggesting possible functional specialization.

Key words

Pseudomonas - Burkholderia - respiratory chain - metabolites - cytochromes - antibiotics

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References

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